• Title of article

    Dual binding site inhibitors of B-RAF kinase

  • Author/Authors

    Ronald L. Wolin، نويسنده , , Scott D. Bembenek، نويسنده , , Jianmei Wei، نويسنده , , Shelby Crawford، نويسنده , , Katherine Lundeen، نويسنده , , Anders Brunmark، نويسنده , , Lars Karlsson، نويسنده , , James P. Edwards، نويسنده , , Jonathan M. Blevitt، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2008
  • Pages
    5
  • From page
    2825
  • To page
    2829
  • Abstract
    Computer aided modeling guided the design of a series of diarylimidazole compounds (11–22) intended to interact with both the ATP and adjacent allosteric binding domains of B-RAF kinase. Their ability to inhibit the function of B-RAF kinase and intracellular ERK1/2 phosphorylation were evaluated.
  • Keywords
    B-Raf , Kinase inhibitors , Diarylimidazoles
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2008
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    799454

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799454