Title of article
Sulfamoyl benzamides as novel CB2 cannabinoid receptor ligands
Author/Authors
Karin Worm، نويسنده , , Q. Jean Zhou، نويسنده , , Christopher T. Saeui، نويسنده , , Rosalyn C. Green، نويسنده , , Joel A. Cassel، نويسنده , , Gabriel J. Stabley، نويسنده , , Robert N. DeHaven، نويسنده , , Nathalie Conway-James، نويسنده , , Christopher J. LaBuda، نويسنده , , Michael Koblish، نويسنده , , Patrick J. Little، نويسنده , , Roland E. Dolle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
2830
To page
2835
Abstract
Sulfamoyl benzamides were identified as a novel series of cannabinoid receptor ligands. Starting from a screening hit 8 that had modest affinity for the cannabinoid CB2 receptor, a parallel synthesis approach and initial SAR are described, leading to compound 27 with 120-fold functional selectivity for the CB2 receptor. This compound produced robust antiallodynic activity in rodent models of postoperative pain and neuropathic pain without traditional cannabinergic side effects.
Keywords
Cannabinoid CB2 receptor , parallel synthesis , Sulfamoyl benzamides , Antiallodynic activity , structure–activity relationship
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799455
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