Author/Authors :
Diane H. Boschelli، نويسنده , , Biqi Wu، نويسنده , , Ana Carolina Barrios Sosa، نويسنده , , Joan Chen، نويسنده , , Magda Asselin، نويسنده , , Derek C. Cole، نويسنده , , Julie Lee، نويسنده , , Xiaoke Yang، نويسنده , , Divya Chaudhary، نويسنده ,
Abstract :
The thieno[2,3-b]pyridine-5-carbonitrile with a 5-indolylamine at C-4 and a phenyl group at C-2 had a moderate activity against PKCθ. Optimization of the groups at C-4 and C-2 led to analog 29, which has an IC50 value of 7.5 nM for the inhibition of PKCθ.
