Title of article
Design, synthesis and evaluation of 2-phenyl-1H-benzo[d]imidazole-4,7-diones as vascular smooth muscle cell proliferation inhibitors
Author/Authors
Chung-Kyu Ryu، نويسنده , , Ra-Young Lee، نويسنده , , Seung-Yon Lee، نويسنده , , Hwa-Jin Chung، نويسنده , , Sang Kook Lee، نويسنده , , Kwang-Hoe Chung، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
2948
To page
2951
Abstract
A series of 2-phenyl-1H-benzo[d]imidazole-4,7-diones were synthesized and tested for their inhibitory activity on the PDGF-stimulated proliferation of rat aortic vascular smooth muscle cells. Among the tested compounds, 6-arylthio-5-chloro-2-phenyl-1H-benzo[d]imidazole-4,7-diones exhibited an potent antiproliferative activity.
Keywords
antiproliferative activity , substitution effects , Smooth muscle cell , 7-dione
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799479
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