Title of article :
New targeting system for antimycotic drugs: β-Glucosidase sensitive Amphotericin B–star poly(ethylene glycol) conjugate
Author/Authors :
Milo? Sedl?k، نويسنده , , Pavel Drabina، نويسنده , , Eli?ka B?lkov?، نويسنده , , Petr ?im?nek، نويسنده , , Vladim?r Buchta، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A new targeting potentially intravenous conjugate Amphotericin B (AMB)–star poly(ethylene glycol) (sPEG) (M = 25,160) has been synthesized and characterized. It contains a β-d-glucopyranoside molecular switch which is sensitive to β-glucosidases (E.C.3.2.1.21). The β-glucosidase-catalyzed release of AMB from the polymeric carrier was proved in vitro by means of spectrophotometry and HPLC.
Keywords :
Amphotericin B , Controlled release in vitro , Drug targeting
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
