Title of article :
Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B
Author/Authors :
David M. Gooden، نويسنده , , Dawn M.Z. Schmidt، نويسنده , , Julie A. Pollock، نويسنده , , Ami M. Kabadi، نويسنده , , Dewey G. McCafferty، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine-specific histone demethylase LSD1 and related enzyme family members such as monoamine oxidases A and B.
Keywords :
Enaminonitrile , Quinozoline , Horner–Wadsworth–Emmons , Cell-based assays
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
