Title of article
IRAK-4 inhibitors. Part 1: A series of amides
Author/Authors
George M. Buckley، نويسنده , , Lewis Gowers، نويسنده , , Alicia Perez Higueruelo، نويسنده , , Kerry Jenkins، نويسنده , , Stephen R. Mack، نويسنده , , Trevor Morgan، نويسنده , , David M. Parry، نويسنده , , William R. Pitt، نويسنده , , Oliver Rausch، نويسنده , , Marianna D. Richard، نويسنده , , Verity Sabin، نويسنده , , Joanne L. Fraser، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
3211
To page
3214
Abstract
The synthesis and profile of a series of amides are described. Some of these compounds were potent IRAK-4 inhibitors and two examples were evaluated in vivo.
Keywords
SAR , Pyridine amide , Docking , Microsomes , Solubility , Thiazole amide , In vivo exposure , Irak , IRAK-4 inhibitor , inflammation , kinase , Suzuki reaction
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799532
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