Title of article
The SAR studies of novel CB2 selective agonists, benzimidazolone derivatives
Author/Authors
Hirofumi Omura، نويسنده , , YOSHIHIRO MATSUDA AND MAKOTO KAWAI، نويسنده , , Akiko Shima، نويسنده , , Yasuhiro Iwata، نويسنده , , Fumitaka Ito، نويسنده , , Tsutomu Masuda، نويسنده , , Atsuko Ohta، نويسنده , , Naoya Makita، نويسنده , , Kiyoyuki Omoto، نويسنده , , Hiromi Sugimoto، نويسنده , , Akira Kikuchi، نويسنده , , Hiroshi Iwata، نويسنده , , Kazuo Ando، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
3310
To page
3314
Abstract
Benzimidazolone derivatives were discovered as novel CB2 selective agonists. Structure Activity Relationship (SAR) studies around them were examined to improve metabolic stability. Compound 39 exhibited excellent metabolic stability in human liver microsomes (HLM) and significant attenuation of the chronic colonic allodynia in the TNBS-treated rats by po administration.
Keywords
Cannabinoid , Metabolic stability , Benzimidazolone , CB2 agonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799552
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