Title of article :
Efficient synthesis and evaluation of bimodal ligand NETA
Author/Authors :
Hyun-Soon Chong، نويسنده , , Hyun A. Song، نويسنده , , Noah Birch، نويسنده , , Thien Le، نويسنده , , Sooyoun Lim، نويسنده , , Xiang Ma، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The efficient and short synthetic route to the structurally novel bimodal ligand NETA for antibody-targeted radiation therapy (radioimmunotherapy, RIT) of cancer was developed. The structure of NETA was determined by X-ray crystallography. The arsenazo-based UV spectroscopic complexation kinetics data suggest that NETA is a promising chelator for use in RIT applications of 212Bi, 213Bi, and 177Lu.
Keywords :
metal binding ligand , 177Lu , 212Bi , 213Bi , Radioimmunotherapy , NETA
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
