Title of article
4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function
Author/Authors
Rajaneesh Anupam، نويسنده , , Abhijit Nayek، نويسنده , , Nicholas J. Green، نويسنده , , Frank J. Grundy، نويسنده , , Tina M. Henkin، نويسنده , , John A. Means، نويسنده , , Stephen C. Bergmeier، نويسنده , , Jennifer V. Hines، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
3541
To page
3544
Abstract
The T box transcription antitermination system is a riboswitch found primarily in Gram-positive bacteria which monitors the aminoacylation of the cognate tRNA and regulates a variety of amino acid-related genes. Novel 4,5-disubstituted oxazolidinones were identified as high affinity RNA molecular effectors that modulate the transcription antitermination function of the T box riboswitch.
Keywords
Riboswitch , Oxazolidinone , T box , Transcription antitermination , RNA ligand
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799595
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