Author/Authors :
Mingde Xia، نويسنده , , Cuifen Hou، نويسنده , , Duane DeMong، نويسنده , , Scott Pollack، نويسنده , , Meng Pan، نويسنده , , James Brackley، نويسنده , , Monica Singer، نويسنده , , Michele Matheis، نويسنده , , Druie Cavender، نويسنده , , Michael Wachter، نويسنده ,
Abstract :
The synthesis and biological evaluation of a series of substituted dipiperidine alcohols are described. Structure–activity relationship studies led to the discovery of potent CCR2 antagonists displaying IC50 values in the nanomolar or subnanomolar range. The cinnamoyl compounds had higher binding affinities than the corresponding urea analogs.
