Title of article
Substituted dipiperidine alcohols as potent CCR2 antagonists
Author/Authors
Mingde Xia، نويسنده , , Cuifen Hou، نويسنده , , Duane DeMong، نويسنده , , Scott Pollack، نويسنده , , Meng Pan، نويسنده , , James Brackley، نويسنده , , Monica Singer، نويسنده , , Michele Matheis، نويسنده , , Druie Cavender، نويسنده , , Michael Wachter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
3562
To page
3564
Abstract
The synthesis and biological evaluation of a series of substituted dipiperidine alcohols are described. Structure–activity relationship studies led to the discovery of potent CCR2 antagonists displaying IC50 values in the nanomolar or subnanomolar range. The cinnamoyl compounds had higher binding affinities than the corresponding urea analogs.
Keywords
MCP-1 , CCR2 antagonist , chemokines
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799599
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