Title of article :
Cubyl amides: Novel P2X7 receptor antagonists
Author/Authors :
Hendra Gunosewoyo، نويسنده , , Jun Liu Guo، نويسنده , , Maxwell R. Bennett، نويسنده , , Mark J. Coster، نويسنده , , Michael Kassiou، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Polycyclic amides 2 and 5–9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity.
Keywords :
P2X7 antagonists , rational drug design , Polycyclic benzamides , Microglia
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
