Title of article
Synthesis and biological activities of reveromycin A and spirofungin A derivatives
Author/Authors
Takeshi Shimizu، نويسنده , , Takeo Usui، نويسنده , , Makoto Fujikura، نويسنده , , Makoto Kawatani، نويسنده , , Tomoharu Satoh، نويسنده , , Kiyotaka Machida، نويسنده , , Naoki Kanoh، نويسنده , , Je-Tae Woo، نويسنده , , Hiroyuki Osada، نويسنده , , Mikiko Sodeoka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
3756
To page
3760
Abstract
Various derivatives of reveromycin A, an inhibitor of eukaryotic cell growth, and spirofungin A, focusing on the 5S hydroxyl group and C18 hemisuccinyl group, were synthesized and their inhibitory effects on both the isoleucyl-tRNA synthetase activity and the survival of osteoclasts, and activities on the morphological reversion of srcts-NRK cells were examined. It was found that 2,3-dihydroreveromycin A is the promising derivative of reveromycin A based on the activity and stability.
Keywords
Spirofungin A , Isoleucyl-tRNA synthetase , osteoclasts , Reveromycin A , srcts-NRK cells
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799650
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