• Title of article

    Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand

  • Author/Authors

    Jeong-Ju Park، نويسنده , , Ji Hyung Lee، نويسنده , , Subhash C. Ghosh، نويسنده , , Gabriel Bricard، نويسنده , , Manjunatha M. Venkataswamy، نويسنده , , Steven A. Porcelli، نويسنده , , Sung-Kee Chung، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2008
  • Pages
    4
  • From page
    3906
  • To page
    3909
  • Abstract
    KRN7000 is an important ligand identified for CD1d protein of APC, and KRN7000/CD1d complex can stimulate NKT cells to release Th1 and Th2 cytokines. In an effort to understand the structure–activity relationships, we have carried out the synthesis of a complete set of the eight KRN7000 stereoisomers, and their biological activities have been examined.
  • Keywords
    Phytosphingosine , ?-GalCer , KRN7000 stereoisomers , NKT cell
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2008
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    799680

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799680