Title of article
Gallic acid-based indanone derivatives as anticancer agents
Author/Authors
Hari Om Saxena، نويسنده , , Uzma Faridi، نويسنده , , Suchita Srivastava، نويسنده , , J.K. Kumar، نويسنده , , M.P. Darokar، نويسنده , , Suaib Luqman، نويسنده , , C.S. Chanotiya، نويسنده , , Vinay Krishna، نويسنده , , Arvind S. Negi، نويسنده , , S.P.S. Khanuja، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
3914
To page
3918
Abstract
Gallic acid-based indanone derivatives have been synthesised. Some of the indanones showed very good anticancer activity in MTT assay. Compounds 10, 11, 12 and 14 possessed potent anticancer activity against various human cancer cell lines. The most potent indanone (10, IC50 = 2.2 μM), against MCF-7, that is, hormone-dependent breast cancer cell line, showed no toxicity to human erythrocytes even at higher concentrations (100 μg/ml, 258 μM). While, indanones 11, 12 and 14 showed toxicities to erythrocytes at higher concentrations.
Keywords
Gallic acid , Indanones , anticancer , osmotic fragility , HMQC
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799682
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