Title of article
Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation
Author/Authors
Christopher M. Tegley، نويسنده , , Vellarkad N. Viswanadhan، نويسنده , , Kaustav Biswas، نويسنده , , Michael J. Frohn، نويسنده , , Tanya A.N. Peterkin، نويسنده , , Catherine Chang، نويسنده , , Roland W. Bürli، نويسنده , , Jennifer H. Dao، نويسنده , , Henrike Veith، نويسنده , , Norma Rogers، نويسنده , , Sean C. Yoder، نويسنده , , Gloria Biddlecome، نويسنده , , Philip Tagari، نويسنده , , Jennifer R. Allen، نويسنده , , Randall W. Hungate، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
3925
To page
3928
Abstract
Inhibition of the PHD2 enzyme has been associated with increased red blood cell levels. From a screening hit, a series of novel hydroxyl-thiazoles were developed as potent PHD2 inhibitors.
Keywords
Proyl hydroxylase inhibitors , HIF-1? , ischemia , hypoxia , anemia , peripheral arterial disease , myocardial infarction , Diabetes , Hydroxy-thiazole , stroke
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799684
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