Title of article
Hypaphorine, an indole alkaloid from Erythrina velutina, induced sleep on normal mice
Author/Authors
Masaaki Ozawa، نويسنده , , Kazuki Honda، نويسنده , , Izumi Nakai، نويسنده , , Akio Kishida، نويسنده , , Ayumi Ohsaki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
3992
To page
3994
Abstract
An indole alkaloid (hypaphorine (1)) was isolated from Brazilian medicinal plant, Erythrina velutina (Leguminosae). This compound was investigated for sleep promoting effects in mice, and the results showed that it significantly increased non-rapid eye movement (NREM) sleep time during the first hour after its administration. The NREM sleep time was enhanced by 33% in the experimental mice when compared to that of the controls. This study therefore confirmed its sleep promoting property.
Keywords
Sleep induced , indole alkaloid , Non-REM , medicinal plant , Erythrina velutina , Hypaphorine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799700
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