Title of article
N-Demethylation of nocathiacin I via photo-oxidation
Author/Authors
Wenying Li، نويسنده , , Stella Huang، نويسنده , , Xiaohong Liu، نويسنده , , John E. Leet، نويسنده , , Joseph L. Cantone، نويسنده , , Kin S. Lam، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
4051
To page
4053
Abstract
In order to improve aqueous solubility of nocathiacin I (1), a potent antibacterial agent, N-demethylation of the amino-sugar moiety was sought. Irradiation of 1 in DMF/CH2Cl2 with UV light of 380 nm led to a cyclic product 2, which was hydrolyzed to yield the desired nocathiacin VI (3). Treatment of 1 with shorter UV light caused trans–cis isomerization of a c–c double bond.
Keywords
Nocathiacin , Photo reaction , Antibacterial , Oxidation , Demethylation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799714
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