Title of article :
3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors
Author/Authors :
Allan Urbach، نويسنده , , Giulio G. Muccioli، نويسنده , , Eric Stern، نويسنده , , Didier M. Lambert، نويسنده , , Jacqueline Marchand-Brynaert، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A series of novel 2-azetidinones (β-lactams) bearing short alkenyl chains at C3 and N1 have been prepared and evaluated in vitro as inhibitors of human FAAH. Compound 9c (1-(4′-pentenoyl-3-(4′-pentenyl)-2-azetidinone)) featured an IC50 value of 4.5 μM and a good selectivity for FAAH versus MGL.
Keywords :
Azetidinone , Enolate alkylation , FAAH inhibition , MGL inhibition
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
