Title of article
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034
Author/Authors
S. Bogen، نويسنده , , A. Arasappan، نويسنده , , W. Pan، نويسنده , , Jesse S. Ruan، نويسنده , , A. Padilla، نويسنده , , A.K. Saksena، نويسنده , , V. Girijavallabhan، نويسنده , , F.G. Njoroge، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
4219
To page
4223
Abstract
Substitutions on the P1 cyclobutyl side chain of SCH 503034 were studied by introduction of hydroxyl and fluoro substituents. Additionally, effects of fluoro substitution on other P1 moieties were evaluated.
Keywords
pK properties , HCV protease inhibitor , Fluorinated P1 , SCH 503034
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799752
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