Title of article :
Design and optimization of potent, selective antagonists of Oxytocin
Author/Authors :
Alan Brown، نويسنده , , Lindsay Brown، نويسنده , , Dave Ellis، نويسنده , , Nicholas Puhalo، نويسنده , , Chris R. Smith، نويسنده , , Olga Wallace، نويسنده , , Lesa Watson، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A novel series of Oxytocin antagonists are described. This series was identified through pharmacophoric overlap of in-house and literature antagonists. Subsequent optimization led to a series of potent, selective antagonists. Several analogues displayed oral bioavailability in vivo in the rat.
Keywords :
Oxytocin , Antagonist , triazole
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
