Title of article :
Structure–activity relationship studies on vitamin D lactam derivatives as vitamin D receptor antagonist
Author/Authors :
Kaori Cho، نويسنده , , Fumito Uneuchi، نويسنده , , Yuko Kato-Nakamura، نويسنده , , Jun-ichi Namekawa، نويسنده , , Seiichi Ishizuka، نويسنده , , Kazuya Takenouchi، نويسنده , , Kazuo Nagasawa، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Structure–activity relationship studies on 1α,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), antagonists of vitamin D, were conducted, focusing on the substituents of the phenyl group. One of the derivatives (23S,25S)-DLAM-1P-3,5(OEt)2, showed potent antagonistic activity with an IC50 of 90 nM.
Keywords :
Vitamin D , Antagonist , DLAM , SAR , Vitamin D receptor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
