Title of article
Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines
Author/Authors
T.D. Venu، نويسنده , , S.A. Khanum، نويسنده , , Aiysha Firdouse، نويسنده , , B.K. Manuprasad، نويسنده , , Sheena Shashikanth، نويسنده , , Riyaz Mohamed، نويسنده , , Bannikuppe Sannanaik Vishwanth، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4409
To page
4412
Abstract
Abstract-Reaction of 6a–f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a–f in excellent yield. The newly synthesized heterocycles were characterized by IR, 1H NMR, and mass spectral data. Compounds 7a–f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.
Keywords
pyrimidines , Synthesis , Anti-inflammatory activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799795
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