Title of article :
4-(1H-Indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors
Author/Authors :
Cynthia M. Shafer، نويسنده , , Mika Lindvall، نويسنده , , Cornelia Bellamacina، نويسنده , , Thomas G. Gesner، نويسنده , , Asha Yabannavar، نويسنده , , Weiping Jia، نويسنده , , Song Lin، نويسنده , , Annette Walter، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
4
From page :
4482
To page :
4485
Abstract :
A series of 4-(4-hydroxyphenyl)-6-phenylpyrimidin-2(1H)-ones were identified by HTS as inhibitors of CDC7. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus on removing potential metabolic liabilities and improving cellular potency.
Keywords :
Pharmacophore model , phenol , Pyrimidone , CDC7 , Indazole
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2008
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
799810
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799810
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