Title of article
Interaction of human serum albumin and its clinically relevant modification with oligoribonucleotides
Author/Authors
Yuliya V. Gerasimova، نويسنده , , Irina A. Erchenko، نويسنده , , Makhmut M. Shakirov، نويسنده , , Tatyana S. Godovikova، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4511
To page
4514
Abstract
Human serum albumin (HSA) was shown to mediate oligoribonucleotide cleavage. Nonenzymatic glycation of HSA decreased the ribonuclease-like activity of the protein. According to 31P NMR data, both native and glycated albumins induced hydrolysis of RNA molecule through 2′,3′-cyclophosphate intermediates. A feasible mechanism of RNA hydrolysis by native albumin and its clinically relevant modification was discussed.
Keywords
Glycation , RNA-hydrolyzing activity , Oligoribonucleotides , human serum albumin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799817
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