Title of article
Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable
Author/Authors
David Buttar، نويسنده , , Mike Edge، نويسنده , , Steve C. Emery، نويسنده , , Martina Fitzek، نويسنده , , Cheryl Forder، نويسنده , , Alison Griffen، نويسنده , , Barry Hayter، نويسنده , , Chris F. Hayward، نويسنده , , Philip J. Hopcroft، نويسنده , , Richard W.A. Luke، نويسنده , , Ken Page، نويسنده , , John Stawpert، نويسنده , , Andy Wright، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4723
To page
4726
Abstract
Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis was carried out by condensation of imidazole aldehydes with methyl pyrimidines. These compounds are lead-like, with low molecular weight, good physical properties and oral bioavailability.
Keywords
inhibitor , Pyrimidine , alkene , Angiogenesis , Tie-2 , kinase , imidazole
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799868
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