Title of article
Synthesis and antiviral properties of some polyphenols related to Salvia genus
Author/Authors
Clémence Queffelec، نويسنده , , Fabrice Bailly، نويسنده , , Gladys Mbemba، نويسنده , , Jean-François Mouscadet، نويسنده , , Sean Hayes، نويسنده , , Zeger Debyser، نويسنده , , Myriam Witvrouw، نويسنده , , Philippe Cotelle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
4736
To page
4740
Abstract
An efficient synthesis of the acid part of salvianolic acid E 2 is described. Compound 2 was obtained from vanillin in 10 steps and 21% overall yield. During the synthesis of 2 an unexpected 5-oxo-4b,9b-dihydroindano[1,2-b]benzofuran rac-12 was isolated. Both compounds together with the acid part of salvianolic acid D were active as HIV-1 integrase inhibitors at the submicromolar level. But they did not inhibit the replication of the virus on MT-4 cells.
Keywords
antivirals , Salvianolic acids , Boron tribromide , Natural polyphenols , Integrase inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799873
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