Title of article
Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates
Author/Authors
Jinyi Xu، نويسنده , , JingYi Yang، نويسنده , , Qian Ran، نويسنده , , Lei Wang، نويسنده , , Jie Liu، نويسنده , , Zhixuan Wang، نويسنده , , Xiaoming Wu، نويسنده , , Weiyi Hua، نويسنده , , Shengtao Yuan، نويسنده , , Luyong Zhang، نويسنده , , Mingqin Shen، نويسنده , , Yongfang Ding، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4741
To page
4744
Abstract
Novel 1-O- and 14-O-derivatives of oridonin were synthesized and biologically evaluated. All of the derivatives exhibited stronger cytotoxicity against six cancer cell lines (BGC-7901, SW-480, HL-60, BEL-7402, A549, and B16) than oridonin in vitro, and some of them were more potent than oridonin and cyclophosphamide in vivo. Compounds Ib and IIg were the most potent with the IC50 values of 0.84 μM for Ib in HL-60 cell and 1.00 μM for IIg in BEL-7402 cell.
Keywords
Oridonin , derivatives , cytotoxicity , Structure–activity relationships , anticancer
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799874
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