Title of article
Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors
Author/Authors
David Bauer، نويسنده , , Douglas A. Whittington، نويسنده , , Angela Coxon، نويسنده , , James Bready، نويسنده , , Shawn P. Harriman، نويسنده , , Vinod F. Patel، نويسنده , , Anthony Polverino، نويسنده , , Jean-Christophe Harmange، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
4844
To page
4848
Abstract
A novel class of potent and selective inhibitors of KDR incorporating an indazole moiety 1 is reported. The discovery, synthesis, and structure–activity relationships of this series of inhibitors have been investigated. The most promising compounds were also profiled to determine their pharmacokinetic properties and evaluated in a VEGF-induced vascular permeability assay.
Keywords
KDR inhibitor , kinase inhibitor , VEGFR-2 inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799902
Link To Document