Author/Authors :
David Bauer، نويسنده , , Douglas A. Whittington، نويسنده , , Angela Coxon، نويسنده , , James Bready، نويسنده , , Shawn P. Harriman، نويسنده , , Vinod F. Patel، نويسنده , , Anthony Polverino، نويسنده , , Jean-Christophe Harmange، نويسنده ,
Abstract :
A novel class of potent and selective inhibitors of KDR incorporating an indazole moiety 1 is reported. The discovery, synthesis, and structure–activity relationships of this series of inhibitors have been investigated. The most promising compounds were also profiled to determine their pharmacokinetic properties and evaluated in a VEGF-induced vascular permeability assay.
