Title of article
Structure–activity relationship study of a novel necroptosis inhibitor, necrostatin-7
Author/Authors
Weihong Zheng، نويسنده , , Alexei Degterev، نويسنده , , Emily Hsu، نويسنده , , Junying Yuan، نويسنده , , Chengye Yuan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4932
To page
4935
Abstract
Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modifications and the structure–activity relationship (SAR) of the Nec-7 series for inhibiting necroptosis.
Keywords
Necroptosis , Caspase-independent cell death , inhibitors , SAR , 3-Aryl-pyrazole , Nec-7 , Thiazolidin-4-one derivatives , Necrostatin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799919
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