Title of article
Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARα/γ dual agonists
Author/Authors
Eunkyung Kim، نويسنده , , Chan Sun Park، نويسنده , , Taedong Han، نويسنده , , Myung-Ho Bae، نويسنده , , Wonee Chong، نويسنده , , Choong Hyun Lee، نويسنده , , Young Ah Shin، نويسنده , , Byung-Nak Ahn، نويسنده , , Mi Kyung Kim، نويسنده , , Chang Yell Shin، نويسنده , , Moon Ho Son، نويسنده , , Jin-Kwan Kim، نويسنده , , Ho Sang Moon، نويسنده , , Hyun Joo Shim، نويسنده , , Eun Jung Kim، نويسنده , , Soon Hoe Kim، نويسنده , , Joong-Yeon Lim، نويسنده , , Chun Ho Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4993
To page
4996
Abstract
Aryl-tetrahydropyridine derivatives were prepared and their PPARα/γ dual agonistic activities were evaluated. Among them, compound (S)-5b was identified as a potent PPARα/γ dual agonist with an EC50 of 1.73 and 0.64 μM in hPPARα and γ, respectively. In diabetic (db/db) mice, compound (S)-5b showed good glucose lowering efficacy and favorable pharmacokinetic properties.
Keywords
Type 2 diabetes , PPARs , PPAR?/? dual agonists , tetrahydropyridine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799933
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