Author/Authors :
Jing Fang، نويسنده , , Adwoa Akwabi-Ameyaw، نويسنده , , Jonathan E. Britton، نويسنده , , Subba R. Katamreddy، نويسنده , , Frank Navas III، نويسنده , , Aaron B. Miller، نويسنده , , Timothy M. Willson and Shawn P. Williams، نويسنده , , David W. Gray، نويسنده , , Lisa A. Orband-Miller، نويسنده , , Jean Shearin، نويسنده , , Dennis Heyer، نويسنده ,
Abstract :
A series of estrogen receptor ligands based on a 3-alkyl naphthalene scaffold was synthesized using an intramolecular enolate-alkyne cycloaromatization as the key step. Several of these compounds bearing a C6-OH group were shown to be high affinity ligands. All compounds had similar ERα and ERβ binding affinity ranging from micromolar to low nanomolar.
