Title of article :
Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4
Author/Authors :
John J. Hall، نويسنده , , Madhavi Sriram، نويسنده , , Tracy E. Strecker، نويسنده , , Justin K. Tidmore، نويسنده , , Christopher J. Jelinek، نويسنده , , G.D. Kishore Kumar، نويسنده , , Mallinath B. Hadimani، نويسنده , , George R. Pettit، نويسنده , , David J. Chaplin، نويسنده , , Mary Lynn Trawick، نويسنده , , Kevin G. Pinney، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A new trifluorinated amino-combretastatin analogue, (Z)-2-(4′-methoxy-3′-aminophenyl)-1-(3,4,5-trifluorophenyl)ethene, prepared by chemical synthesis, was found to be a potent inhibitor of tubulin assembly (IC50 = 2.9 μM), and cytotoxic against selected human cancer cell lines. This new lead compound is among the most active from a group of related structural modifications.
Keywords :
Combretastatin , Inhibitors of tubulin assembly , Anti-cancer agents
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
