Title of article
Design, synthesis and antiproliferative activity of two new heteroannelated (−)-muricatacin mimics
Author/Authors
Velimir Popsavin، نويسنده , , Bojana Sre?o، نويسنده , , Goran Benedekovi?، نويسنده , , Mirjana Popsavin، نويسنده , , Jovana Francuz، نويسنده , , Vesna Koji?، نويسنده , , Gordana Bogdanovic، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
5182
To page
5185
Abstract
Two new (−)-muricatacin mimics bearing a furano-furanone ring and an oxygen isostere in the side chain have been designed and synthesized and their in vitro antiproliferative activity was evaluated against several human tumour cell lines. Both analogues showed an increased activity against HL-60 cells with 17- and 185-fold higher potency than (−)-muricatacin. A straightforward synthesis of (−)-muricatacin is also disclosed.
Keywords
Muricatacin mimics , Bioisostere , antitumour activity , Wittig reaction , Goniofufurone mimics
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799975
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