Title of article
Synthesis and biological activity of anticoccidial agents: 5,6-Diarylimidazo[2,1-b][1,3]thiazoles
Author/Authors
Andrew Scribner، نويسنده , , Susan Meitz، نويسنده , , Michael Fisher، نويسنده , , Matthew Wyvratt، نويسنده , , Penny Leavitt، نويسنده , , Paul Liberator، نويسنده , , Anne Gurnett، نويسنده , , Chris Brown، نويسنده , , John Mathew، نويسنده , , Donald Thompson، نويسنده , , Dennis Schmatz، نويسنده , , Tesfaye Biftu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
5263
To page
5267
Abstract
Novel 5,6-diarylimidazo[2,1-b][1,3]thiazoles bearing an amine substituent at the imidazothiazole 2-position have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 10.
Keywords
PKG inhibitor , Imidazothiazole , Anticoccidial , Antiprotozoan , Protein kinase G
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799995
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