Title of article :
Synthesis and biological activity of anticoccidial agents: 5,6-Diarylimidazo[2,1-b][1,3]thiazoles
Author/Authors :
Andrew Scribner، نويسنده , , Susan Meitz، نويسنده , , Michael Fisher، نويسنده , , Matthew Wyvratt، نويسنده , , Penny Leavitt، نويسنده , , Paul Liberator، نويسنده , , Anne Gurnett، نويسنده , , Chris Brown، نويسنده , , John Mathew، نويسنده , , Donald Thompson، نويسنده , , Dennis Schmatz، نويسنده , , Tesfaye Biftu، نويسنده ,
Abstract :
Novel 5,6-diarylimidazo[2,1-b][1,3]thiazoles bearing an amine substituent at the imidazothiazole 2-position have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 10.
Keywords :
PKG inhibitor , Imidazothiazole , Anticoccidial , Antiprotozoan , Protein kinase G
