Title of article :
Modification of the side chain of micromolide, an anti-tuberculosis natural product
Author/Authors :
Ke-Hai Yuan، نويسنده , , Rong He، نويسنده , , Baojie Wan، نويسنده , , Yuehong Wang، نويسنده , , Guido F. Pauli، نويسنده , , Scott G. Franzblau، نويسنده , , Alan P. Kozikowski، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
This paper describes a series of modifications of the side chain of micromolide, an anti-tuberculosis natural product. Most of the synthesized compounds showed significantly decreased activities, which suggests that the long aliphatic side chain of micromolide and its double bond are essential to its activity.
Keywords :
lactone , natural product , SAR , tuberculosis , Micromolide
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
