Title of article :
Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis
Author/Authors :
Caroline M. Reid، نويسنده , , Charles Ebikeme، نويسنده , , MICHAEL P. BARRETT، نويسنده , , Eva-Maria Patzewitz، نويسنده , , Sylke Müller، نويسنده , , David J. Robins، نويسنده , , Andrew Sutherland، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Efficient synthetic routes have been developed for the preparation of two new polyazamacrocycles tagged with structural motifs recognised by the Trypanosoma brucei P2 aminopurine transporter. Biological testing of these compounds showed highly selective anti-protozoal activity against trypanosomes.
Keywords :
Macrocycles , Trypanosomes , P2 transporter , Anti-protozoal
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
