Title of article :
Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA
Author/Authors :
Rob C. Oslund، نويسنده , , Nathan Cermak، نويسنده , , Christophe L.M.J. Verlinde، نويسنده , , Michael H. Gelb، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Simplified analogs of YM-26734, a known inhibitor of secreted phospholipase A2 (sPLA2) group IIA, were synthesized and found to also display potent inhibition at low nanomolar concentrations. Analogs were based on the didodecanoylphloroglucinol portion of YM-26734 which contains the predicted active site calcium binding group.
Keywords :
Lipid mediators , Eicosanoids , inflammation , structure-based drug design , phospholipases
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
