Title of article
Optimization of a series of potent and selective ketone histone deacetylase inhibitors
Author/Authors
Giovanna Pescatore، نويسنده , , Olaf Kinzel، نويسنده , , Barbara Attenni، نويسنده , , Ottavia Cecchetti، نويسنده , , Fabrizio Fiore، نويسنده , , Massimiliano Fonsi، نويسنده , , Michael Rowley، نويسنده , , Carsten Schultz-Fademrecht، نويسنده , , Sergio Serafini، نويسنده , , Christian Steinkühler، نويسنده , , Philip Jones، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
5528
To page
5532
Abstract
Histone deacetylase (HDAC) inhibitors offer a promising strategy for cancer therapy and the first generation HDAC inhibitors are currently in the clinic. Herein we describe the optimization of a series of ketone small molecule HDAC inhibitors leading to potent and selective class I HDAC inhibitors with good dog PK.
Keywords
HDAC inhibitors , Alkyl ketone , Zinc binding group
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800050
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