Synthesis of potent water-soluble tissue transglutaminase inhibitors
Author/Authors :
Martin Griffin، نويسنده , , Alexandre Mongeot، نويسنده , , Russell Collighan، نويسنده , , Robert E. Saint، نويسنده , , Richard A. Jones، نويسنده , , Ian G.C. Coutts، نويسنده , , Daniel L. Rathbone، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
4
From page :
5559
To page :
5562
Abstract :
Dipeptide-based sulfonium peptidylmethylketones derived from 6-diazo-5-oxo-l-norleucine (DON) have been investigated as potential water-soluble inhibitors of extracellular transglutaminase. The lead compounds were prepared in four steps and exhibited potent activity against tissue transglutaminase.
