Title of article :
Novel 5-HT1A/1B/1D receptors antagonists with potent 5-HT reuptake inhibitory activity
Author/Authors :
Halina T. Serafinowska، نويسنده , , Frank E. Blaney، نويسنده , , Peter J. Lovell، نويسنده , , Giancarlo G. Merlo، نويسنده , , Claire M. Scott، نويسنده , , Paul W. Smith، نويسنده , , Kathryn R. Starr، نويسنده , , Jeannette M. Watson، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Novel 2-methyl-5-quinolinyl-1-piperazinylalkyl-3,4-dihydro-2H-1,4-benzoxazin-3-ones showing high affinities for the 5-HT1A/1B/1D receptors coupled with potent 5-HT reuptake inhibitory activity have been discovered. This is the first report describing docking of the lead compound 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2H-1,4-benzoxazin-3(4H)-one 1, into a model of the 5-HT transporter and the 5-HT1A receptor model.
Keywords :
Potent 5-HT1A/1B/1D receptors antagonists , 4-benzoxazin-3(4H)-one , 5-HT1A receptor model , Potent 5-HT reuptake inhibitory activity , 5-HT transporter model
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
