Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons

Constraining the catechol aryl ether moiety of bastadins by incorporation into a macrocyle is not necessary in order to mimic the effects of these marine natural products on neuronal calcium homeostasis. Simple, acyclic analogs that embody the ‘western’ or ‘eastern’ parts of bastadins were found to evoke comparable responses with bastadin 5.