Title of article
Regioselective nitration of Nα,N1-bis(trifluoroacetyl)-l-tryptophan methyl ester: Efficient synthesis of 2-nitro and 6-nitro-N-trifluoroacetyl-l-tryptophan methyl ester
Author/Authors
Andrew S. Osborne، نويسنده , , Phanneth Som، نويسنده , , Jessica L. Metcalf، نويسنده , , Robert S. Phillips، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
5750
To page
5752
Abstract
Nitration of Nα,N1-bis(trifluoroacetyl)-l-tryptophan methyl ester with HNO3 in acetic anhydride at 0 °C provides Nα-trifluoroacetyl-2-nitro-l-tryptophan methyl ester in 67% yield, whereas nitration in trifluoroacetic acid at 0 °C gives Nα-trifluoroacetyl-6-nitro-l-tryptophan methyl ester in 69% yield.
Keywords
Nitrotryptophan , indole , tryptophan , nitration
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800101
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