Title of article :
Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides
Author/Authors :
Sanjib Bhattacharya، نويسنده , , Jason N. LaButti، نويسنده , , Derrick R. Seiner، نويسنده , , Kent S. Gates، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Protein tyrosine phosphatases (PTPs) are cysteine-dependent enzymes that play a central role in cell signaling. Organic hydroperoxides cause thiol-reversible, oxidative inactivation of PTP1B in a manner that mirrors the endogenous signaling agent hydrogen peroxide.
Keywords :
Protein tyrosine phosphatase , Peroxides , Hydroperoxides , Enzyme inactivation
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
