Title of article
Development of novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists
Author/Authors
Takashi Mizutani، نويسنده , , Tsuyoshi Nagase، نويسنده , , Sayaka Ito، نويسنده , , Yasuhisa Miyamoto، نويسنده , , Takeshi Tanaka، نويسنده , , Norihiro Takenaga، نويسنده , , Shigeru Tokita، نويسنده , , Nagaaki Sato، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
6041
To page
6045
Abstract
Novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives were identified as potent human H3 receptor inverse agonists. After systematic modification of lead 5a, the potent and selective analog 5r was identified. Elimination of hERG K+ channel and human α1A-adrenoceptor activities is the main focus of the present study.
Keywords
?1A-Adrenoceptor , Quinazolinone , Histamine release assay , hERG K+ channel , Histamine H3 receptor inverse agonists
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800165
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