Title of article :
The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist
Author/Authors :
Kevin P. Madauss، نويسنده , , Randy K. Bledsoe، نويسنده , , Iain Mclay، نويسنده , , Eugene L. Stewart، نويسنده , , Iain J. Uings، نويسنده , , Gordon Weingarten، نويسنده , , Timothy M. Willson and Shawn P. Williams، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The amino-pyrazole 2,6-dichloro-N-ethyl benzamide 1 is a selective GR agonist with dexamethasone-like in vitro potency. Its X-ray crystal structure in the GR LBD (Glucocorticoid ligand-binding domain) is described and compared to other reported structures of steroidal GR agonists in the GR LBD (3E7C).
Keywords :
benzamides , crystal structure , Aminopyrazol , Glucocorticoid receptor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
