Author/Authors :
Gloria A. Breault، نويسنده , , Janelle Comita-Prevoir، نويسنده , , Charles J. Eyermann، نويسنده , , Bolin Geng، نويسنده , , Randy Petrichko، نويسنده , , Peter Doig، نويسنده , , Elise Gorseth، نويسنده , , Brian Noonan، نويسنده ,
Abstract :
A successful scaffold-hopping approach gave a novel series of inhibitors of bacterial glutamate racemase (MurI). Early SAR studies of the 8-benzyl pteridine-6,7-diones led to compounds with micromolar enzyme potency and antibacterial activity.
Keywords :
7-dione , Glutamate racemase , MurI inhibitor , 8-Benzyl pteridine-6
