Title of article
Exploring 8-benzyl pteridine-6,7-diones as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria
Author/Authors
Gloria A. Breault، نويسنده , , Janelle Comita-Prevoir، نويسنده , , Charles J. Eyermann، نويسنده , , Bolin Geng، نويسنده , , Randy Petrichko، نويسنده , , Peter Doig، نويسنده , , Elise Gorseth، نويسنده , , Brian Noonan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
6100
To page
6103
Abstract
A successful scaffold-hopping approach gave a novel series of inhibitors of bacterial glutamate racemase (MurI). Early SAR studies of the 8-benzyl pteridine-6,7-diones led to compounds with micromolar enzyme potency and antibacterial activity.
Keywords
7-dione , Glutamate racemase , MurI inhibitor , 8-Benzyl pteridine-6
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800178
Link To Document