Title of article
Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5′-hydroxybutitaxel
Author/Authors
Haibo Ge، نويسنده , , Jianmei Wang، نويسنده , , Margaret M. Kayser، نويسنده , , Richard H. Himes، نويسنده , , Gunda I. Georg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
6165
To page
6167
Abstract
A highly efficient kinetic resolution of racemic cis-4-(2-tert-butyldimethylsilyloxy-1,1-dimethyl)ethyl-3-tert-butyldimethylsilyloxy-azetidin-2-one with 7-O-triethylsilylbaccatin III was carried out to furnish 10-O-acetyl-5′-hydroxybutitaxel after removal of the silyl protecting groups. The compound was 50% as active as paclitaxel in a tubulin assembly assay and showed significantly decreased activity against MCF7 cell proliferation compared to paclitaxel.
Keywords
Paclitaxel analogues , Semisynthesis , kinetic resolution , Tubulin assembly , cytotoxicity , MCF7 , NCI/ADR RES
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800193
Link To Document