Author/Authors :
Cory Stiff، نويسنده , , David R. Graber، نويسنده , , Atli Thorarensen، نويسنده , , Brian D. Wakefield، نويسنده , , Keith R. Marotti، نويسنده , , Earline P. Melchior، نويسنده , , Michael T. Sweeney، نويسنده , , Fusen Han، نويسنده , , Douglas C. Rohrer، نويسنده , , Gary E. Zurenko، نويسنده , , Donna L. Romero، نويسنده ,
Abstract :
The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents has been described in a recent series of papers. This paper describes the discovery of 1-acylindazol-3-ols as a novel bioisostere of an anthranilic acid. The synthesis and structure–activity relationships of the indazol bioisosteres are described herein.
Keywords :
Bioisosteres , Translation inhibitors , Indazol , Protein binding , Antibacterials
