Author/Authors :
Wayne Vaccaro، نويسنده , , Tram Huynh، نويسنده , , John Lloyd، نويسنده , , Karnail Atwal، نويسنده , , Heather J. Finlay، نويسنده , , Paul Levesque، نويسنده , , Mary Lee Conder، نويسنده , , Tonya Jenkins-West، نويسنده , , Hong Shi، نويسنده , , Lucy Sun، نويسنده ,
Abstract :
A series of dihydropyrazolopyrimidine inhibitors of KV1.5 (IKur) have been identified. The synthesis, structure–activity relationships and selectivity against several other ion channels are described.
Keywords :
Dihydropyrazolopyrimidine , Kv1.5 , IKur , Potassium channel , ion channels , Atrial fibrillation
